Scientific Research

We have undertaken a program of non-clinical research in collaboration with leading research institutions in Australia and the UK.  The research has focused on understanding the biological mechanism(s) of action for OPAL A at the molecular, cellular and skin levels and understanding the biological basis for the observed attractive safety profile of OPAL A.  The findings to date suggest that there are multiple bioactive molecules in OPAL A, which have multiple modes of action, including wound debridement and anti-bacterial activity.  The scientific results to date also suggest a number of other therapeutic effects; appropriate experimental work is being undertaken to confirm or reject these identified effects.

The primary centre of research is The Centre for Cell Biology and Cutaneous Research at the Blizard Institute, which is part of Queen Mary University of London.  The majority of the research to date has been carried out by Dr Giuseppe Trigiante and by a PhD student Sreekanth Vootukuri Reddy under the direction of Professor Michael Philpott, who stepped down from being the Lead at the Centre after commencement of this research so as to be able to spend more time on the Phoenix Eagle Project.  The enzymatic work was directed by Emeritus Professor Keith Brocklehurst.

The work at the Blizard Institute arose from findings in work undertaken by Proteomics International of Perth, directed by its founder and CEO Dr Richard Lipscombe.

The results to date are of great interest to the scientists involved in the research.  Keith, globally renowned for his work on cysteine proteinases, and particularly papain, has described some of the results as “remarkable and unexpected”.

We have recently engaged on a full-time basis an exceptionally gifted researcher whose work on a project at the Blizard for a major pharmaceutical company had come to an end.  Catherine Chronnell will undertake a planned program of cell-based assays on the effects of OPAL A and Variants of OPAL A on a number of identified target indications.

It is of significance to note that the studies that are being undertaken in London have been approved by AusIndustry and the Australian Tax Office as being eligible for the R&D Tax Concession for work done outside of Australia on the ground that there are no suitable capabilities within Australia for this cutting edge research.

Due to the confidentiality of the results of the work, academic papers and non-confidential presentations will not be made available (except to parties who have signed Confidentiality Agreements) or published in journals until the relevant patent applications have been published.

The first of our second generation priority-date patent applications is about to be filed in Europe.

We have just executed a Confidentiality Agreement with the University of Florida and are in the process of putting in place the necessary agreements for work to be undertaken by Professor Greg Schultz and Assistant Research Professor Dan Gibson.  The first body of work will be an experiment to validate one of Giuseppe’s patentable inventions.

We have also just accepted a proposal for the first in vivo study of OPAL A, which is to be undertaken at the CNR Instituto di NeuroScienze in Milan.  Giuseppe has been working with the Instituto in establishing the detailed protocols for this first study.  The Instituto will make the necessary applications for Ethics Committee approval and the authorisation of the study by the Italian Ministry of Health once the formal contractual documentation has been executed.

Two other important members of our Science Team are Professor Allison Cowin of The University of South Australia and Dr Fraser Russell of The University of the Sunshine Coast in Queensland.  While some of the  results from The University of the  Sunshine Coast are confidential, Dr Russell and his colleagues published a paper entitled, ‘Effect of the  novel  wound healing agent, OPAL A on leukotriene B4 production in human neutrophils and 5-lipoxygenase activity’ in the December 2011 edition of Wound Practice & Research.

Contact Us

Phoenix Eagle Company Pty Ltd
Suite 5
531 Hay Street
Subiaco, WA 6008
Tel: 0419 094 748

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